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As the loss of POLRMT results in severe mitochondrial dysfunction in cardiac muscle 70 , a similar mitochondrial dysfunction should occur in beta-cells with the loss or dysfunction of POLRMT, resulting in insulin resistance and diabetes mellitus

This mechanistic distinction is considered an important biological basis behind the efficacy differences observed in the Mazdutide vs Semaglutide head-to-head trial presented at ADA 2026

The FDA is expected to release a verdict on or before Aug

Gonzalez-Flecha et al., 1991a, 1991b

In fact, from a database of 186 mutant alleles that are now known, a reasonably clear pattern has emerged (see Table 18-2 )